Protective Effects of Galium verum L. Extract against Cardiac IschemiaReperfusion Injury in Spontaneously Hypertensive Rats
المؤلفون المشاركون
Barudzic, Nevena S.
Srejovic, Ivan
Mitrovic, Slobodanka
Jeremic, Jovana
Bradic, Jovana
Petkovic, Anica
Turnic, Tamara Nikolic
Sobot, Tanja
Ponorac, Nenad
Ravic, Marko
Tomovic, Marina
Jakovljevic, Vladimir Lj.
Zivkovic, Vladimir I.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-04
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Galium verum L.
(G.
verum, lady’s bedstraw) is a perennial herbaceous plant, belonging to the Rubiaceae family.
It has been widely used throughout history due to multiple therapeutic properties.
However, the effects of this plant species on functional recovery of the heart after ischemia have still not been fully clarified.
Therefore, the aim of our study was to examine the effects of methanol extract of G.
verum on myocardial ischemia/reperfusion (I/R) injury in spontaneously hypertensive rats (SHR), with a special emphasis on the role of oxidative stress.
Rats involved in the research were divided randomly into two groups: control (spontaneously hypertensive rats (SHR)) and G.
verum group, including SHR rats treated with the G.
verum extract (500 mg/kg body weight per os) for 4 weeks.
At the end of the treatment, in vivo cardiac function was assessed by echocardiography.
Rats were sacrificed and blood samples were taken for spectrophotometric determination of systemic redox state.
Hearts from all rats were isolated and retrogradely perfused according to the Langendorff technique.
After a stabilization period, hearts were subjected to 20-minute ischemia, followed by 30-minute reperfusion.
Levels of prooxidants were spectrophotometrically measured in coronary venous effluent, while antioxidant enzymes activity was assessed in heart tissue.
Cell morphology was evaluated by hematoxylin and eosin (HE) staining.
4-week treatment with G.
verum extract alleviated left ventricular hypertrophy and considerably improved in vivo cardiac function.
Furthermore, G.
verum extract preserved cardiac contractility, systolic function, and coronary vasodilatory response after ischemia.
Moreover, it alleviated I/R-induced structural damage of the heart.
Additionally, G.
verum extract led to a drop in the generation of most of the measured prooxidants, thus mitigating cardiac oxidative damage.
Promising potential of G.
verum in the present study may be a basis for further researches which would fully clarify the mechanisms through which this plant species triggers cardioprotection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bradic, Jovana& Zivkovic, Vladimir I.& Srejovic, Ivan& Jakovljevic, Vladimir Lj.& Petkovic, Anica& Turnic, Tamara Nikolic…[et al.]. 2019. Protective Effects of Galium verum L. Extract against Cardiac IschemiaReperfusion Injury in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1203522
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bradic, Jovana…[et al.]. Protective Effects of Galium verum L. Extract against Cardiac IschemiaReperfusion Injury in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1203522
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bradic, Jovana& Zivkovic, Vladimir I.& Srejovic, Ivan& Jakovljevic, Vladimir Lj.& Petkovic, Anica& Turnic, Tamara Nikolic…[et al.]. Protective Effects of Galium verum L. Extract against Cardiac IschemiaReperfusion Injury in Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1203522
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203522
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر