Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease
المؤلفون المشاركون
Tang, Ying
Zhang, Shi-Jie
Huang, Shun
Lu, Xinyi
Chen, Qu-Bo
Zhang, Dapeng
Li, Wanyan
Ao, Ran
Leung, Feona Chung-Yin
Zhang, Zhimin
Huang, Jisheng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is the most common neurodegenerative disease.
The accumulation of amyloid beta (Aβ) is the main pathology of AD.
Metformin, a well-known antidiabetic drug, has been reported to have AD-protective effect.
However, the mechanism is still unclear.
In this study, we tried to figure out whether metformin could activate insulin-degrading enzyme (IDE) to ameliorate Aβ-induced pathology.
Morris water maze and Y-maze results indicated that metformin could improve the learning and memory ability in APPswe/PS1dE9 (APP/PS1) transgenic mice.
18F-FDG PET-CT result showed that metformin could ameliorate the neural dysfunction in APP/PS1 transgenic mice.
PCR analysis showed that metformin could effectively improve the mRNA expression level of nerve and synapse-related genes (Syp, Ngf, and Bdnf) in the brain.
Metformin decreased oxidative stress (malondialdehyde and superoxide dismutase) and neuroinflammation (IL-1β and IL-6) in APP/PS1 mice.
In addition, metformin obviously reduced the Aβ level in the brain of APP/PS1 mice.
Metformin did not affect the enzyme activities and mRNA expression levels of Aβ-related secretases (ADAM10, BACE1, and PS1).
Meanwhile, metformin also did not affect the mRNA expression levels of Aβ-related transporters (LRP1 and RAGE).
Metformin increased the protein levels of p-AMPK and IDE in the brain of APP/PS1 mice, which might be the key mechanism of metformin on AD.
In conclusion, the well-known antidiabetic drug, metformin, could be a promising drug for AD treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Xinyi& Huang, Shun& Chen, Qu-Bo& Zhang, Dapeng& Li, Wanyan& Ao, Ran…[et al.]. 2020. Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203911
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Xinyi…[et al.]. Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1203911
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Xinyi& Huang, Shun& Chen, Qu-Bo& Zhang, Dapeng& Li, Wanyan& Ao, Ran…[et al.]. Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1203911
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1203911
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر