Anticancer Activity of Liquid Treated with Microwave Plasma-Generated Gas through Macrophage Activation
المؤلفون المشاركون
Choi, Eun Ha
Baik, Ku Youn
Lee, Chae Bok
Seo, Il Hwan
Chae, Myoung-Won
Park, Jae Woo
Uhm, Han Sup
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-31
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Reactive nitrogen species (RNS), including nitric oxide (NO⋅) has been known as one of the key regulatory molecules in the immune system.
In this study, we generated RNS-containing water treated with microwave plasma-generated gas in which the major component was nitric oxide (PGNO), and the effect on the macrophage polarization was investigated.
The RNS-containing water was diluted in complete cell culture media (PGNO-solution) into the concentration that did not induce cell death in RAW 264.7 murine macrophages.
PGNO-solution upregulates M1-type macrophage activation and downregulates the characteristics of M2-type macrophage at the transcriptional level.
In addition, the PGNO-solution-treated M2-like macrophages had higher potential in killing melanoma cells.
The anticancer potential was also investigated in a syngeneic mouse model.
Our results show that PGNO-solution has the potential to convert the fate of macrophages, suggesting PGNO-solution treatment as a supportive method for controlling the function of macrophages under the tumor microenvironment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Chae Bok& Seo, Il Hwan& Chae, Myoung-Won& Park, Jae Woo& Choi, Eun Ha& Uhm, Han Sup…[et al.]. 2020. Anticancer Activity of Liquid Treated with Microwave Plasma-Generated Gas through Macrophage Activation. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204083
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Chae Bok…[et al.]. Anticancer Activity of Liquid Treated with Microwave Plasma-Generated Gas through Macrophage Activation. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1204083
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Chae Bok& Seo, Il Hwan& Chae, Myoung-Won& Park, Jae Woo& Choi, Eun Ha& Uhm, Han Sup…[et al.]. Anticancer Activity of Liquid Treated with Microwave Plasma-Generated Gas through Macrophage Activation. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1204083
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204083
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر