“Special K” Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments
المؤلفون المشاركون
Monteiro, Marta Chagas
Fontes-Júnior, Enéas Andrade
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Lima, Rafael Rodrigues
Gomes, Antônio Rafael Quadros
Paraense, Ricardo Sousa de Oliveira
Cartágenes, Sabrina C.
Carvalheiro, Taiana Cristina Vilhena Sarmento
de Sousa, Thais Miranda
Crespo-López, Maria Elena
Prediger, Rui Daniel
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Ketamine is used in clinical practice as an anesthetic that pharmacologically modulates neurotransmission in postsynaptic receptors, such as NMDA receptors.
However, widespread recreational use of ketamine in “party drug” worldwide since the 1990s quickly spread to the Asian orient region.
Thus, this study aimed at investigating the behavioral and oxidative effects after immediate withdrawal of intermittent administration of ketamine in adolescent female rats.
For this, twenty female Wistar rats were randomly divided into two groups: control and ketamine group (n=10/group).
Animals received ketamine (10 mg/kg/day) or saline intraperitoneally for three consecutive days.
Three hours after the last administration, animals were submitted to open field, elevated plus-maze, forced swim tests, and inhibitory avoidance paradigm.
Twenty-four hours after behavioral tests, the blood and hippocampus were collected for the biochemical analyses.
Superoxide dismutase, catalase, nitrite, and lipid peroxidation (LPO) were measured in the blood samples.
Nitrite and LPO were measured in the hippocampus.
The present findings demonstrate that the early hours of ketamine withdrawal induced oxidative biochemistry unbalance in the blood samples, with elevated levels of nitrite and LPO.
In addition, we showed for the first time that ketamine withdrawal induced depressive- and anxiety-like profile, as well as short-term memory impairment in adolescent rodents.
The neurobehavioral deficits were accompanied by the hippocampal nitrite and LPO-elevated levels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cartágenes, Sabrina C.& Fernandes, Luanna Melo Pereira& Carvalheiro, Taiana Cristina Vilhena Sarmento& de Sousa, Thais Miranda& Gomes, Antônio Rafael Quadros& Monteiro, Marta Chagas…[et al.]. 2019. “Special K” Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204165
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cartágenes, Sabrina C.…[et al.]. “Special K” Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1204165
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cartágenes, Sabrina C.& Fernandes, Luanna Melo Pereira& Carvalheiro, Taiana Cristina Vilhena Sarmento& de Sousa, Thais Miranda& Gomes, Antônio Rafael Quadros& Monteiro, Marta Chagas…[et al.]. “Special K” Drug on Adolescent Rats: Oxidative Damage and Neurobehavioral Impairments. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1204165
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1204165
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر