HIF1α-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia
المؤلفون المشاركون
Bo, Lulong
Bian, Jinjun
Shao, Chao
Lin, Shengwei
Liu, Sudan
Jin, Peipei
Lu, Wenbin
Li, Na
Zhang, Yan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Ouabain, a steroid binding to the Na+/K+-ATPase, has several pharmacological effects.
In addition to the recognized effects of blood pressure, there is more convincing evidence suggesting that ouabain is involved in immunologic functions and inflammation.
Hypoxia-inducible factor 1α (HIF-1α) is a metabolic regulator which plays a considerable role in immune responses.
Previous studies had shown that HIF-1α-induced glycolysis results in functional reshaping in macrophages.
In this study, we investigated the role of glycolytic pathway activation in the anti-inflammatory effect of ouabain.
We found that ouabain is involved in anti-inflammatory effects both in vivo and in vitro.
Additionally, ouabain can inhibit LPS-induced upregulation of GLUT1 and HK2 at the transcriptional level.
GM-CSF pretreatment almost completely reversed the inhibitory effect of ouabain on LPS-induced release of proinflammatory cytokines.
Alterations in glycolytic pathway activation were required for the anti-inflammatory effect of ouabain.
Ouabain can significantly inhibit the upregulation of HIF-1α at the protein level.
Our results also revealed that the overexpression of HIF-1α can reverse the anti-inflammatory effect of ouabain.
Thus, we conclude that the HIF-1α-dependent glycolytic pathway is essential for the anti-inflammatory effect of ouabain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shao, Chao& Lin, Shengwei& Liu, Sudan& Jin, Peipei& Lu, Wenbin& Li, Na…[et al.]. 2019. HIF1α-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1205009
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shao, Chao…[et al.]. HIF1α-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1205009
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shao, Chao& Lin, Shengwei& Liu, Sudan& Jin, Peipei& Lu, Wenbin& Li, Na…[et al.]. HIF1α-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1205009
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205009
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر