Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease
المؤلفون المشاركون
Kwiatkowska, Iwona
Hermanowicz, Justyna M.
Mysliwiec, Michal
Pawlak, Dariusz
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-30
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Chronic kidney disease (CKD) occurrence is rising all over the world.
Its presence is associated with an increased risk of premature death from cardiovascular disease (CVD).
Several explanations of this link have been put forward.
It is known that in renal failure, an array of metabolites cannot be excreted, and they accumulate in the organism.
Among them, some are metabolites of tryptophan (TRP), such as indoxyl sulfate and kynurenine.
Scientists have become interested in them in the context of inducing vascular damage in the course of chronic kidney impairment.
Experimental evidence suggests the involvement of TRP metabolites in the progression of chronic kidney disease and atherosclerosis separately and point to oxidative stress generation as one of the main mechanisms that is responsible for worsening those states.
Since it is known that blood levels of those metabolites increase significantly in renal failure and that they generate reactive oxygen species (ROS), which lead to endothelial injury, it is reasonable to suspect that products of TRP metabolism are the missing link in frequently occurring atherosclerosis in CKD patients.
This review focuses on reports that shed a light on TRP metabolites as contributing factors to vascular damage in the progression of impaired kidney function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kwiatkowska, Iwona& Hermanowicz, Justyna M.& Mysliwiec, Michal& Pawlak, Dariusz. 2020. Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1205183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kwiatkowska, Iwona…[et al.]. Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1205183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kwiatkowska, Iwona& Hermanowicz, Justyna M.& Mysliwiec, Michal& Pawlak, Dariusz. Oxidative Storm Induced by Tryptophan Metabolites: Missing Link between Atherosclerosis and Chronic Kidney Disease. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1205183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر