Extracts or Active Components from Acorus gramineus Aiton for Cognitive Function Impairment: Preclinical Evidence and Possible Mechanisms
المؤلفون المشاركون
Li, Yan
Zhang, Xi-Le
Huang, Yan-Ran
Zheng, Yan-Yan
Zhang, Li-Ping
Zheng, Guo-qing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-33، 33ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-25
دولة النشر
مصر
عدد الصفحات
33
التخصصات الرئيسية
الملخص EN
Extracts or active components from Acorus gramineus Aiton (EAAGA) have been clinically used for cognition impairment more than hundreds of years and are still used in modern times in China and elsewhere worldwide.
Previous studies reported that EAAGA improves cognition impairment in animal models.
Here, we conducted a preclinical systematic review to assess the current evidence of EAAGA for cognition impairment.
We searched 7 databases up until June 2019.
Methodological quality for each included studies was accessed according to the CAMARADES 10-item checklist.
The primary outcome measures were neurobehavioral function scores evaluated by the Morris water maze test, electrical Y-maze test, step-down test, radial eight-arm maze test, and step-through test.
The secondary outcome measures were mechanisms of EAAGA for cognition function.
Finally, 34 studies involving 1431 animals were identified.
The quality score of studies range from 1 to 6, and the median was 3.32.
Compared with controls, the results of the meta-analysis indicated EAAGA exerted a significant effect in decreasing the escape latency and error times and in increasing the length of time spent in the platform quadrant and the number of platform crossings representing learning ability and memory function (all P<0.01).
The possible mechanisms of EAAGA are largely through anti-inflammatory, antioxidant, antiapoptosis activities, inhibition of neurotoxicity, regulating synaptic plasticity, protecting cerebrovascular, stimulating cholinergic system, and suppressing astrocyte activation.
In conclusion, EAAGA exert potential neuroprotective effects in experimental cognition impairment, and EAAGA could be a candidate for cognition impairment treatment and further clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yan& Zhang, Xi-Le& Huang, Yan-Ran& Zheng, Yan-Yan& Zheng, Guo-qing& Zhang, Li-Ping. 2020. Extracts or Active Components from Acorus gramineus Aiton for Cognitive Function Impairment: Preclinical Evidence and Possible Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2020, no. 2020, pp.1-33.
https://search.emarefa.net/detail/BIM-1205204
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yan…[et al.]. Extracts or Active Components from Acorus gramineus Aiton for Cognitive Function Impairment: Preclinical Evidence and Possible Mechanisms. Oxidative Medicine and Cellular Longevity No. 2020 (2020), pp.1-33.
https://search.emarefa.net/detail/BIM-1205204
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yan& Zhang, Xi-Le& Huang, Yan-Ran& Zheng, Yan-Yan& Zheng, Guo-qing& Zhang, Li-Ping. Extracts or Active Components from Acorus gramineus Aiton for Cognitive Function Impairment: Preclinical Evidence and Possible Mechanisms. Oxidative Medicine and Cellular Longevity. 2020. Vol. 2020, no. 2020, pp.1-33.
https://search.emarefa.net/detail/BIM-1205204
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205204
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر