Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease

المؤلفون المشاركون

Zhang, Yunlong
Qian, Lin-chao
Huang, Shuqiong
Chen, Chaojun
Xu, Pingyi
Liu, Yan
Du, Ting
Zhang, Wenlong
Lu, Weiye
Peng, Zhichao
Sun, Xiangdong
Zhu, Xiaoqin
Wen, Lei

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-27، 27ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-11-03

دولة النشر

مصر

عدد الصفحات

27

التخصصات الرئيسية

الأحياء

الملخص EN

Alzheimer’s disease (AD) is a common neurodegenerative disease, characterized by cognitive dysfunction; however, the therapeutic strategies are not fully understood.

Huang-Lian-Jie-Du-Decoction (HLJDD) is a famous traditional Chinese herbal formula that has been widely used clinically to treat dementia.

Recently, according to previous study and our clinical practice, we generate a new modification of HLJDD (named modified-HLJDD).

In this study, we indicated that modified-HLJDD attenuated learning and memory deficiencies in Aβ1-42 oligomer-induced AD model, and we confirmed the exact metabolites in modified-HLJDD solution, as compared with HLJDD by UHPLC-Q-TOF-MS.

Using GC-Q-TOF/MS-based metabolomics, we identified adenosine as the potential significant metabolite, responsible for modified-HLJDD regulating energy metabolism and synaptic plasticity in AD model.

We also revealed that the potential underlying mechanism of modified-HLJDD in AD model may involve NMDA receptor-mediated glutamatergic transmission and adenosine/ATPase/AMPK cascade.

Moreover, we also indicated the differential gut microbiota which mainly involved Firmicutes, Bacteroidetes, Proteobacteria, and Actinobacteria at the phylum level upon modified-HLJDD treatment in AD model.

Based on the correlation of metabolomic analysis with microbiome analysis, we clarified that Dorea is the most affected microbiota with adenosine upon modified-HLJDD treatment in AD model.

Thus, our study suggests that modified-HLJDD may serve as a potential therapeutic drug in treating AD.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liu, Yan& Du, Ting& Zhang, Wenlong& Lu, Weiye& Peng, Zhichao& Huang, Shuqiong…[et al.]. 2019. Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-27.
https://search.emarefa.net/detail/BIM-1205635

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liu, Yan…[et al.]. Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-27.
https://search.emarefa.net/detail/BIM-1205635

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liu, Yan& Du, Ting& Zhang, Wenlong& Lu, Weiye& Peng, Zhichao& Huang, Shuqiong…[et al.]. Modified Huang-Lian-Jie-Du Decoction Ameliorates Aβ Synaptotoxicity in a Murine Model of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-27.
https://search.emarefa.net/detail/BIM-1205635

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1205635