Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol
المؤلفون المشاركون
de Carvalho, Tayana Silva
Cardoso, Patrick Bruno
Santos-Silva, Mateus
Lima-Bastos, Sávio
Luz, Waldo Lucas
Assad, Nadyme
Kauffmann, Nayara
Passos, Adelaide
Brasil, Alódia
Bahia, Carlomagno Pacheco
Moraes, Suellen
Gouveia, Amauri
de Jesus Oliveira Batista, Evander
Oliveira, Karen Renata Matos Herculano
Herculano, Anderson Manoel
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Anxiety is a common symptom associated with high caffeine intake.
Although the neurochemical mechanisms of caffeine-induced anxiety remain unclear, there are some evidences suggesting participation of oxidative stress.
Based on these evidences, the current study is aimed at evaluating the possible protective effect of alpha-tocopherol (TPH) against anxiety-like behavior induced by caffeine (CAF) in zebrafish.
Adult animals were treated with CAF (100 mg/kg) or TPH (1 mg/kg)+CAF before behavioral and biochemical evaluations.
Oxidative stress in the zebrafish brain was evaluated by a lipid peroxidation assay, and anxiety-like behavior was monitored using light/dark preference and novel tank diving test.
Caffeine treatment evoked significant elevation of brain MDA levels in the zebrafish brain, and TPH treatment prevented this increase.
Caffeine treatment also induced anxiety-like behavior, while this effect was not observed in the TPH+CAF group.
Taken together, the current study suggests that TPH treatment is able to inhibit oxidative stress and anxiety-like behavior evoked by caffeine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brasil, Alódia& Bahia, Carlomagno Pacheco& Moraes, Suellen& Gouveia, Amauri& de Jesus Oliveira Batista, Evander& Oliveira, Karen Renata Matos Herculano…[et al.]. 2019. Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1205667
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brasil, Alódia…[et al.]. Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1205667
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brasil, Alódia& Bahia, Carlomagno Pacheco& Moraes, Suellen& Gouveia, Amauri& de Jesus Oliveira Batista, Evander& Oliveira, Karen Renata Matos Herculano…[et al.]. Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1205667
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1205667
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر