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Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer
المؤلفون المشاركون
Shang, Wenjing
Xie, Zhongdong
Lu, Fengying
Fang, Daoquan
Tang, Tianbin
Bi, Ruichun
Chen, Lingli
Jiang, Lei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-18
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
Thioredoxin-1 (Trx-1) is a small redox protein, which plays an important role in many biological processes.
Although increased expression of Trx-1 in various solid tumors has been reported, the prognostic significance and function of Trx-1 in human gastric cancer (GC) are still unclear.
Here, we investigated the clinical and prognostic significance of Trx-1 expression and the function and mechanism of Trx-1 in human GC.
Methods.
We analyzed Trx-1 mRNA expression from the GEO database and Trx-1 protein expression in 144 GC tissues using immunohistochemistry.
Effects of Trx-1 on GC cell were assessed in vitro and in vivo through Trx-1 knockdown or overexpression.
The antitumor effects of the Trx-1 inhibitor, PX-12, on GC cells were investigated.
PTEN and p-AKT expressions were evaluated by Western blotting.
Results.
Increased Trx-1 expression was found in GC tissues and associated with poor prognosis and aggressive clinicopathological characteristics in patients with GC.
High Trx-1 expression predicted poor prognosis, and its expression was an independent prognostic factor for overall survival of GC patients.
Knockdown of Trx-1 expression inhibited GC cell growth, migration, and invasion in vitro and tumor growth and lung metastasis in vivo.
Conversely, overexpression of Trx-1 promoted GC cell growth, migration, and invasion.
We also found that PX-12 inhibited GC cell growth, migration, and invasion.
Overexpression of Trx-1 caused a decrease in PTEN and increase in p-AKT levels whereas silencing Trx-1 caused an increase in PTEN and decrease in p-AKT levels in GC cells.
Inhibition of AKT signaling pathway by MK2206 also inhibited GC cell growth, migration, and invasion.
Conclusion.
Our results indicate that Trx-1 may be a promising prognostic indicator and therapeutic target for GC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shang, Wenjing& Xie, Zhongdong& Lu, Fengying& Fang, Daoquan& Tang, Tianbin& Bi, Ruichun…[et al.]. 2019. Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1206296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shang, Wenjing…[et al.]. Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1206296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shang, Wenjing& Xie, Zhongdong& Lu, Fengying& Fang, Daoquan& Tang, Tianbin& Bi, Ruichun…[et al.]. Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1206296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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