Predicting Cognitive Decline in Parkinson’s Disease with Mild Cognitive Impairment: A One-Year Observational Study
المؤلفون المشاركون
Cheng, Shih-Jung
Chen, Pei-Hao
Cheng, Fang-Yu
Shaw, Jin-Siang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We conducted an observational study to investigate clinical predictors of cognitive decline in patients with mild cognitive impairment (MCI), with a focus on patients with Parkinson’s disease (PD) and Alzheimer’s disease (AD).
The study was performed with detailed neuropsychological testing, a portable device for gait analysis, and a comprehensive geriatric assessment for patients with MCI.
Cognitive decline was defined as subjective cognitive impairment with an objective decline in the Mini-Mental State Examination (MMSE) ≥2 points at the one-year follow-up.
Participants (n = 74) had a median age of 70 (interquartile range 60–79) years, and 45.9% of them were women.
At the end of the study, 17.6% of the patients with MCI had a cognitive decline.
Although no differences were observed between groups at the baseline cognitive study, patients with PD-MCI demonstrated more cognitive decline than patients with AD-MCI (28.6% vs.
7.7% p = 0.03).
Patients with PD-MCI had more physical disabilities, including scores of instrumental activities of daily living (IADL), Tinetti balance, and gait scores, and some Timed Up and Go components.
Initial Clinical Dementia Rating—Sum of Boxes score was a better predictor of future cognitive decline than MMSE in PD-MCI.
For predicting the occurrence of cognitive decline in PD-MCI, the prediction accuracy increased from the reduced model (AUC = 0.822, p<0.001) to the full model (a total of five independent variables, AUC = 0.974, p<0.001).
Given the potentially modifiable predictor, our findings also highlight the importance of identifying sleep quality and the ability to perform IADL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Pei-Hao& Cheng, Fang-Yu& Cheng, Shih-Jung& Shaw, Jin-Siang. 2020. Predicting Cognitive Decline in Parkinson’s Disease with Mild Cognitive Impairment: A One-Year Observational Study. Parkinson’s Disease،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206533
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Pei-Hao…[et al.]. Predicting Cognitive Decline in Parkinson’s Disease with Mild Cognitive Impairment: A One-Year Observational Study. Parkinson’s Disease No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1206533
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Pei-Hao& Cheng, Fang-Yu& Cheng, Shih-Jung& Shaw, Jin-Siang. Predicting Cognitive Decline in Parkinson’s Disease with Mild Cognitive Impairment: A One-Year Observational Study. Parkinson’s Disease. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1206533
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1206533
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر