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Neuroinflammation and Myelin Status in Alzheimer’s Disease, Parkinson’s Disease, and Normal Aging Brains: A Small Sample Study
المؤلفون المشاركون
Han, Fei
Perrin, Richard J.
Wang, Qing
Wang, Yong
Perlmutter, Joel S.
Morris, John C.
Benzinger, Tammie L. S.
Xu, Jinbin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-04
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Microglia and astrocytes play important roles in mediating the immune processes and nutritional support in the central nervous system (CNS).
Neuroinflammation has been indicated in the progression of neurodegenerative diseases Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Chronic neuroinflammation with sustained activation of microglia and astrocytes may affect white matter tracts and disrupt communication between neurons.
Recent studies indicate astrogliosis may inhibit remyelination in demyelinating disorders such as multiple sclerosis.
In this study, we investigated the relationship between neuroinflammation and myelin status in postmortem human brain tissue (n = 15 including 6 AD, 5 PD, and 4 age-matched, neurologically normal controls (NC)).
We conducted systematic and quantitative immunohistochemistry for glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor molecule 1 (Iba1), amyloid beta, and highly phosphorylated tau (tauopathy).
White matter intactness was evaluated by myelin and axon staining in adjacent brain tissue sections.
Eight of 15 cases (4 AD, 3 PD, and 1 NC) showed increased immunoreactivity for microglia and astrocytes in the white matter that connects striatum and cortex.
Quantitative analysis of these 8 cases showed a significant negative correlation between GFAP (but not Iba-1) and myelin (but not axon) staining in white matter (r2 = 0.78, p<0.005).
Tau, but not amyloid beta plaques, is significantly higher in AD vs.
PD and NC.
Tau burden increases with age in AD cases.
These observations indicate that astrocytosis in white matter is associated with loss of myelin in AD, PD, and normal aging and that tau is a potent biomarker for AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Han, Fei& Perrin, Richard J.& Wang, Qing& Wang, Yong& Perlmutter, Joel S.& Morris, John C.…[et al.]. 2019. Neuroinflammation and Myelin Status in Alzheimer’s Disease, Parkinson’s Disease, and Normal Aging Brains: A Small Sample Study. Parkinson’s Disease،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1207013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Han, Fei…[et al.]. Neuroinflammation and Myelin Status in Alzheimer’s Disease, Parkinson’s Disease, and Normal Aging Brains: A Small Sample Study. Parkinson’s Disease No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1207013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Han, Fei& Perrin, Richard J.& Wang, Qing& Wang, Yong& Perlmutter, Joel S.& Morris, John C.…[et al.]. Neuroinflammation and Myelin Status in Alzheimer’s Disease, Parkinson’s Disease, and Normal Aging Brains: A Small Sample Study. Parkinson’s Disease. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1207013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1207013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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