Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine
المؤلفون المشاركون
Moya, Pablo R.
Cavieres, Alvaro
Campos-Estrada, Carolina
Moya, Yanneth
Maldonado, Rocío
González-Vargas, René
Bustamante, María Leonor
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Alterations in neuroinflammatory processes have been suggested to contribute to the development of Schizophrenia (SZ); one component of the inflammatory system that has been linked to this disorder is interleukin-6 (IL-6).
The minor allele of rs2228145, a functional polymorphism in the IL-6 receptor gene, has been associated to elevated IL-6 plasma levels and increased inflammatory activity, making it an interesting candidate to study as a possible factor underlying clinical heterogeneity in SZ.
We studied a sample of 100 patients undergoing treatment with clozapine.
Their symptoms were quantified by Brief Psychotic Rating Scale; those with the lowest scores (“remitted”) were compared with the highest (“clozapine treatment resistant”).
We determined allelic frequencies for rs2228145 and IL-6 plasma levels.
Our results do not support a role of IL-6 in response to treatment with clozapine.
Further studies accounting for potential confounding factors are necessary.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cavieres, Alvaro& Campos-Estrada, Carolina& Moya, Yanneth& Maldonado, Rocío& González-Vargas, René& Bustamante, María Leonor…[et al.]. 2019. Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine. Schizophrenia Research and Treatment،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1208059
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cavieres, Alvaro…[et al.]. Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine. Schizophrenia Research and Treatment No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1208059
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cavieres, Alvaro& Campos-Estrada, Carolina& Moya, Yanneth& Maldonado, Rocío& González-Vargas, René& Bustamante, María Leonor…[et al.]. Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine. Schizophrenia Research and Treatment. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1208059
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1208059
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر