Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation
المؤلفون المشاركون
Heredia, Margarita
Palomero, Jesús
de la Fuente, Antonio
Criado, José María
Yajeya, Javier
Devesa, Jesús
Devesa, Pablo
Vicente-Villardón, José Luis
Riolobos, Adelaida S.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-20
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
We previously demonstrated that the administration of GH immediately after severe motor cortex injury, in rats, followed by rehabilitation, improved the functionality of the affected limb and reexpressed nestin in the contralateral motor cortex.
Here, we analyze whether these GH effects depend on a time window after the injury and on the reexpression of nestin and actin.
Injured animals were treated with GH (0.15 mg/kg/day) or vehicle, at days 7, 14, and 35 after cortical ablation.
Rehabilitation was applied at short and long term (LTR) after the lesion and then sacrificed.
Nestin and actin were analyzed by immunoblotting in the contralateral motor cortex.
Giving GH at days 7 or 35 after the lesion, but not 14 days after it, led to a remarkable improvement in the functionality of the affected paw.
Contralateral nestin and actin reexpression was clearly higher in GH-treated animals, probably because compensatory brain plasticity was established.
GH and immediate rehabilitation are key for repairing brain injuries, with the exception of a critical time period: GH treatment starting 14 days after the lesion.
Our data also indicate that there is not a clear plateau in the recovery from a brain injury in agreement with our data in human patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Heredia, Margarita& Palomero, Jesús& de la Fuente, Antonio& Criado, José María& Yajeya, Javier& Devesa, Jesús…[et al.]. 2018. Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation. Neural Plasticity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210247
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Heredia, Margarita…[et al.]. Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation. Neural Plasticity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1210247
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Heredia, Margarita& Palomero, Jesús& de la Fuente, Antonio& Criado, José María& Yajeya, Javier& Devesa, Jesús…[et al.]. Motor Improvement of Skilled Forelimb Use Induced by Treatment with Growth Hormone and Rehabilitation Is Dependent on the Onset of the Treatment after Cortical Ablation. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1210247
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210247
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر