Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome
المؤلفون المشاركون
Scott-McKean, Jonah J.
Roque, Adriano L.
Surewicz, Krystyna
Johnson, Mark W.
Surewicz, Witold K.
Costa, Alberto C. S.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-10
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The Ts65Dn mouse is the most studied animal model of Down syndrome.
Past research has shown a significant reduction in CA1 hippocampal long-term potentiation (LTP) induced by theta-burst stimulation (TBS), but not in LTP induced by high-frequency stimulation (HFS), in slices from Ts65Dn mice compared with euploid mouse-derived slices.
Additionally, therapeutically relevant doses of the drug memantine were shown to rescue learning and memory deficits in Ts65Dn mice.
Here, we observed that 1 μM memantine had no detectable effect on HFS-induced LTP in either Ts65Dn- or control-derived slices, but it rescued TBS-induced LTP in Ts65Dn-derived slices to control euploid levels.
Then, we assessed LTP induced by four HFS (4xHFS) and found that this form of LTP was significantly depressed in Ts65Dn slices when compared with LTP in euploid control slices.
Memantine, however, did not rescue this phenotype.
Because 4xHFS-induced LTP had not yet been characterized in Ts65Dn mice, we also investigated the effects of picrotoxin, amyloid beta oligomers, and soluble recombinant human prion protein (rPrP) on this form of LTP.
Whereas ≥10 μM picrotoxin increased LTP to control levels, it also caused seizure-like oscillations.
Neither amyloid beta oligomers nor rPrP had any effect on 4xHFS-induced LTP in Ts65Dn-derived slices.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Scott-McKean, Jonah J.& Roque, Adriano L.& Surewicz, Krystyna& Johnson, Mark W.& Surewicz, Witold K.& Costa, Alberto C. S.. 2018. Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome. Neural Plasticity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1210510
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Scott-McKean, Jonah J.…[et al.]. Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome. Neural Plasticity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1210510
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Scott-McKean, Jonah J.& Roque, Adriano L.& Surewicz, Krystyna& Johnson, Mark W.& Surewicz, Witold K.& Costa, Alberto C. S.. Pharmacological Modulation of Three Modalities of CA1 Hippocampal Long-Term Potentiation in the Ts65Dn Mouse Model of Down Syndrome. Neural Plasticity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1210510
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210510
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر