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Changes of KEAP1NRF2 and IKBNF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types
المؤلفون المشاركون
Izevskaya, Vera L.
Porokhovnik, Lev
Ershova, Elizaveta
Veiko, Natalia
Kutsev, S. I.
Martynov, A. V.
Kaliyanov, Andrew A.
Sergeeva, Vasilina A.
Abramova, Margarita S.
Kameneva, L. V.
Veiko, V. P.
Kostyuk, Svetlana V.
Malinovskaya, Elena M.
Dolgikh, Olga A.
Pisarev, Vladimir M.
Filev, Anton D.
Chudakova, Julia M.
Konkova, Marina S.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-20
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Cell-free DNA (cfDNA) is a circulating DNA of nuclear and mitochondrial origin mainly derived from dying cells.
Recent studies have shown that cfDNA is a stress signaling DAMP (damage-associated molecular pattern) molecule.
We report here that the expression profiles of cfDNA-induced factors NRF2 and NF-κB are distinct depending on the target cell’s type and the GC-content and oxidation rate of the cfDNA.
Stem cells (MSC) have shown higher expression of NRF2 without inflammation in response to cfDNA.
In contrast, inflammatory response launched by NF-κB was dominant in differentiated cells HUVEC, MCF7, and fibroblasts, with a possibility of transition to massive apoptosis.
In each cell type examined, the response for oxidized cfDNA was more acute with higher peak intensity and faster resolution than that for nonoxidized cfDNA.
GC-rich nonoxidized cfDNA evoked a weaker and prolonged response with proinflammatory component (NF-κB) as predominant.
The exploration of apoptosis rates after adding cfDNA showed that cfDNA with moderately increased GC-content and lightly oxidized DNA promoted cell survival in a hormetic manner.
Novel potential therapeutic approaches are proposed, which depend on the current cfDNA content: either preconditioning with low doses of cfDNA before a planned adverse impact or eliminating (binding, etc.) cfDNA when its content has already become high.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kostyuk, Svetlana V.& Porokhovnik, Lev& Ershova, Elizaveta& Malinovskaya, Elena M.& Konkova, Marina S.& Kameneva, L. V.…[et al.]. 2018. Changes of KEAP1NRF2 and IKBNF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210808
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kostyuk, Svetlana V.…[et al.]. Changes of KEAP1NRF2 and IKBNF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1210808
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kostyuk, Svetlana V.& Porokhovnik, Lev& Ershova, Elizaveta& Malinovskaya, Elena M.& Konkova, Marina S.& Kameneva, L. V.…[et al.]. Changes of KEAP1NRF2 and IKBNF-κB Expression Levels Induced by Cell-Free DNA in Different Cell Types. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1210808
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210808
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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