PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3KAKT and cGMPPKG Signaling
المؤلفون المشاركون
Yao, Yongliang
Lu, Xiao-Jie
Zhang, Qinghui
Xiang, Shihao
Liu, Qingqian
Gu, Tao
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-01
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Aims.
Accumulating evidence reveals that PPARγ plays a unique role in the regulation of hepatic fibrosis and hepatic stellate cells (HSCs) activation.
This study was aimed at investigating the role of PPARγ in hypoxia-induced hepatic fibrogenesis and its possible mechanism.
Methods.
Rats used for CCl4-induced hepatic fibrosis model were exposed to hypoxia for 8 hours each day.
Rats exposed to hypoxia were treated with or without the PPARγ agonist rosiglitazone.
Liver sections were stained with HE and Sirius red staining 8 weeks later.
HSCs were exposed to hypoxic environment in the presence or absence of rosiglitazone, and expression of PPARγ and two fibrosis markers, α-SMA and desmin, were measured using western blot and immunofluorescence staining.
Next, levels of PPARγ, α-SMA, and desmin as well as PKG and cGMP activity were detected using PI3K/AKT and a cGMP activator or inhibitor.
Results.
Hypoxia promoted the induction and progress of hepatic fibrosis and HSCs activation.
Meanwhile, rosiglitazone significantly antagonized the effects induced by hypoxia.
Signaling by sGC/cGMP/PKG promoted the inhibitory effect of PPARγ on hypoxia-induced activation of HSCs.
Moreover, PI3K/AKT signaling or PDE5 blocked the above response of PPARγ.
Conclusion.
sGC/cGMP/PKG and PI3K/AKT signals act on PPARγ synergistically to attenuate hypoxia-induced HSC activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Qinghui& Xiang, Shihao& Liu, Qingqian& Gu, Tao& Yao, Yongliang& Lu, Xiao-Jie. 2018. PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3KAKT and cGMPPKG Signaling. PPAR Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212526
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Qinghui…[et al.]. PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3KAKT and cGMPPKG Signaling. PPAR Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212526
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Qinghui& Xiang, Shihao& Liu, Qingqian& Gu, Tao& Yao, Yongliang& Lu, Xiao-Jie. PPARγ Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3KAKT and cGMPPKG Signaling. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212526
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212526
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر