EZH1 Is Associated with TCP-Induced Bone Regeneration through Macrophage Polarization
المؤلفون المشاركون
Jia, Xiaoshi
Xu, Hudi
Miron, Richard J.
Yin, Chengcheng
Zhang, Xiaoxin
Wu, Min
Zhang, Yufeng
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-30
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Macrophages have been found to regulate the effects of biomaterials throughout the entire tissue repair process as an antigen-presenting cell.
As a well-defined osteoconductive biomaterial for bone defect regeneration, tricalcium phosphate (TCP) has been found to facilitate a favourable osteoimmunomodulatory response that can shift macrophage polarization towards the M2 phenotype.
In the present study, our group discovered that a histone methyltransferase enhancer of zeste1 (EZH1) was drastically downregulated in Thp1 cells stimulated by TCP, indicating that EZH1 may participate in the macrophage phenotype shifting.
Furthermore, the NF-κB pathway in macrophages was significantly downregulated through stimulation of TCP, suggesting a potential interaction between EZH1 and the NF-κB pathway.
Utilizing gene knock-down therapy in macrophages, it was found that depletion of EZH1 induced M2 macrophage polarization but did not downregulate NF-κB.
When the NF-κB pathway was inhibited, the expression of EZH1 was significantly downregulated, suggesting that the inhibition of EZH1 may be regulated by the NF-κB pathway.
These novel findings provide valuable insights into a potential gene target system that controls M2 macrophage polarization which ultimately favours a microenvironment suitable for bone repair.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jia, Xiaoshi& Xu, Hudi& Miron, Richard J.& Yin, Chengcheng& Zhang, Xiaoxin& Wu, Min…[et al.]. 2018. EZH1 Is Associated with TCP-Induced Bone Regeneration through Macrophage Polarization. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213512
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jia, Xiaoshi…[et al.]. EZH1 Is Associated with TCP-Induced Bone Regeneration through Macrophage Polarization. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213512
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jia, Xiaoshi& Xu, Hudi& Miron, Richard J.& Yin, Chengcheng& Zhang, Xiaoxin& Wu, Min…[et al.]. EZH1 Is Associated with TCP-Induced Bone Regeneration through Macrophage Polarization. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213512
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1213512
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر