تشخيص عوز أنزيم G6PD في مستشفى الأطفال الجامعي

الملخص EN

Background: favism is a common disease in our country which becomes an endemic during sprinting season due to the huge amount of fava bean eaten where the emergency service is crowed by favic patients who need blood transfusion.

Objective: This study aims to evaluate the medical and economic benefit of quantitative measuring of the G6PD enzyme to favic patients after the blood transfusion of two months interval.

Methodology: during sprinting of year 2015, 116 patients who were accepted in emergency room with suspicion of favism after the medical history, symptoms, personal and familial history.

After blood transfusion had been done, parents were asked to come back to hospital to measure the G6PD to the their infant after 8 months interval to confirm the diagnosis of favism.

Results: the ages of the patients ranged from six months and twelve years with mean age 3.5 years.

The percentage of male was 69%, female 31%, the male:female ratio was2.1:1.

The familial history of favism was positive in 69% of patients.

In 18% of patients there had acute hemolysis after eating fava bean.

89% of patients had eaten fava bean , 5% had contact with fava bean or the flower of fava bean.

2.5% of patients the acute hemolysis episode had followed the nursing from mother who had eaten fava bean.

four individual patients mentioned that they had eaten straw berry, hummus, falafel, peas.

After 2 months of laboratory surveillance, only 6% of patients came back to hospital to measure the G6PD enzyme.

Conclusion: This is no benefit of asking the parents of children to measure the enzyme after two months from blood transfusion because the diagnosis is simple from the history and physical examination and from the antecedent personal and familial history and the simple laboratory tests.

It should be concentrated on the measuring of the enzyme to the siblings of the patients to prevents the acute hemolytic episode due to favasrom bean eating and we have to ask the parents not to feed their children fava bean until rouling out the G6PD deficiency even in the females.