تحضير عدد من المركبات خماسية و سداسية الحلقة غير المتجانسة المشتقة من 2-امينو بنزوثايازول

الملخص EN

In this paper, number of heterocyclic compound with five and six membered, Such as substituted imidazole, triazin and thiazolidine.

The compound N-(1, 3-benzothiazol-2-yl)-2-chloro acetamide was prepared from the reaction of the 2-amino benzothiazole with chloroacetyl chloride.

The product N-(1, 3-benzothiazol -2-yl) -2-chloro acetamide was reacted with thiourea and urea to prepare both 4-(1.3-benzothiazol -2-yl amino) -1, 5-dihydro -2H-imidazole -2-thione and 4-(1, 3-benzothiazol -2-yl amino) -1, 5-dihydro -2H-imidazol -2-one, respectively.

As did compound N-(1, 3-benzothiazol -2-yl) -2-chloro acetamide with thiosemicarbazide and semicarbazide to prepared the two compounds 5-(1, 3-benzothiazol -2-yl amino) -1, 6-dihydro -1, 2, 4-triazine -3(2H)-thione and 5-(1, 3-benzothiazol -2-yl amino) -1, 6-dihydro -1, 2, 4-triazine -3(2H)-one, respectively.

Also compound N-(1, 3-benzothiazol -2-yl) -2-chloro acetamide with ammonium thiocyanate to prepare the compound 3-(1, 3-benzothiazol -2-yl amino) thiazolidin -4-one.

From the reaction of compound N-(1, 3-benzothiazol -2-yl) -2-chloro acetamide with phenyl thiourea attended 4-(1, 3-benzothiazol -2-yl amino) -1-phenyl -1, 5 -dihydro - 2H-imidazole -2-thio.

Also from the reaction of 2-amino benzothiazole with phthalic anhydride or malic anhydride attended compounds2- (1, 3-benzothiazol -2-yl carbonyl) benzoic acid and 4-(1, 3-benzothiazol -2-yl amino) -4-oxobut-2-enoic acid and 2-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) benzamide and 3-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) acrylamide, respectively.

And by reaction compound 2- (1, 3-benzothiazol -2-yl carbonyl) benzoic acid and 4-(1, 3-benzothiazol -2-yl amino) -4-oxobut-2-enoic acid or 2-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) benzamide and 3-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) acrylamide with o-phenylene diamine attended compounds 2-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) benzamide and 3-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) acrylamide, respectively.

The synthesized compounds are identified by physical melting points, color change and spectroscopic methods such as IR, heterocyclic compound with five and six membered, Such as substituted imidazole, triazin and thiazolidine.

The compound N-(1, 3-benzothiazol-2-yl)-2-chloro acetamide was prepared from the reaction of the 2-amino benzothiazole with chloroacetyl chloride.

The product N-(1, 3-benzothiazol -2-yl) -2-chloro acetamide was reacted with thiourea and urea to prepare both 4-(1.3-benzothiazol -2-yl amino) -1, 5-dihydro -2H-imidazole -2-thione and 4-(1, 3-benzothiazol -2-yl amino) -1, 5-dihydro -2H-imidazol -2-one, respectively.

As did compound N-(1, 3-benzothiazol -2-yl) -2-chloro acetamide with thiosemicarbazide and semicarbazide to prepared the two compounds 5-(1, 3-benzothiazol -2-yl amino) -1, 6-dihydro -1, 2, 4-triazine -3(2H)-thione and 5-(1, 3-benzothiazol -2-yl amino) -1, 6-dihydro -1, 2, 4-triazine -3(2H)-one, respectively.

Also compound N-(1, 3-benzothiazol -2-yl) -2-chloro acetamide with ammonium thiocyanate to prepare the compound 3-(1, 3-benzothiazol -2-yl amino) thiazolidin -4-one.

From the reaction of compound N-(1, 3-benzothiazol -2-yl) -2-chloro acetamide with phenyl thiourea attended 4-(1, 3-benzothiazol -2-yl amino) -1-phenyl -1, 5 -dihydro - 2H-imidazole -2-thio.

Also from the reaction of 2-amino benzothiazole with phthalic anhydride or malic anhydride attended compounds2- (1, 3-benzothiazol -2-yl carbonyl) benzoic acid and 4-(1, 3-benzothiazol -2-yl amino) -4-oxobut-2-enoic acid and 2-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) benzamide and 3-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) acrylamide, respectively.

And by reaction compound 2- (1, 3-benzothiazol -2-yl carbonyl) benzoic acid and 4-(1, 3-benzothiazol -2-yl amino) -4-oxobut-2-enoic acid or 2-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) benzamide and 3-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) acrylamide with o-phenylene diamine attended compounds 2-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) benzamide and 3-(1H-benzoimidazol -2-yl) –N-(1, 3-benzothiazol -2-yl) acrylamide, respectively.

The synthesized compounds are identified by physical melting points, color change and spectroscopic methods such as IR, proton-NMR.