التقدير الطيفي للبيبرازين في المستحضر الصيدلاني باستخدام الكاشف 5,3- ثنائي نيترو حامض السالسيليك

الملخص EN

A simple spectrophotometric method for the determination of piperazine hexa- hydrate was developed.

The method was based on the proton transfer reaction with 3, 5- dinitrosalicylic acid (DNS) in basic solution to form yellow product showing a maximum orbance at 410 nm with molar orptivity of 8350 l/mol.

cm.

The method is obeyed Beer's law over the concentration range 0.5-20 µg/ml.

The average recovery % of the method is 99.12% and RSD % of the method is less than 2% .

The method was applied for the determination of piperazine hexahydrate in pharmaceutical formulation as elixir and the results were in good agreement with the standard addition method