Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity

العناوين الأخرى

اصطناع المشتق الجديد1- ثنائي فينيل إينامين حمض الأسكوربيك و دراسة نشاطه البيولوجي

العنوان الموازي

اصطناع المشتق الجديد1- ثنائي فينيل إينامين حمض الأسكوربيك و دراسة نشاطه البيولوجي

المؤلفون المشاركون

Shalar, Muhammad Mutazz Ghazi
Mirza, Jumah
Shriteh, Thana

المصدر

Journal of Natural Sciences, Life and Applied Sciences

العدد

المجلد 5، العدد 2 (30 يونيو/حزيران 2021)، ص ص. 113-128، 16ص.

الناشر

المركز القومي للبحوث

تاريخ النشر

2021-06-30

دولة النشر

فلسطين (قطاع غزة)

عدد الصفحات

16

التخصصات الرئيسية

الأحياء

الملخص EN

The new enamine [1- Diphenyl enamine ascorbic acid] has been prepared according to two methods: The first method was “The reaction between ascorbic acid and diphenylamine” has been done directly, however the yield was relatively low.

The second method was “the reaction between ascorbic acid and diphenylamine” which has been carried out through three steps: In the first step, the hydroxyl groups in (5, 6) position have been protected using the acetone, in the second step, the hydroxyl groups in (2, 3) position have been protected using iodide methyl.

The obtained compound (5, 6-dioxolan-2, 3-metoxy ascorbic acid) have been reacted with Diphenylamine to obtain the target molecule in the third step'' the structural determination has been confirmed using spectroscopy methods (FT-IR, 1H-NMR, 13C-NMR).

The target compound gave very good biological activity against Gram-positive bacteria (Staphylococcus Aureus) and Gram-negative (Pseudomonas Aeruginosa) bacteria, with Gentamicin as a reference active compound.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Shalar, Muhammad Mutazz Ghazi& Mirza, Jumah& Shriteh, Thana. 2021. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences،Vol. 5, no. 2, pp.113-128.
https://search.emarefa.net/detail/BIM-1286967

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Shalar, Muhammad Mutazz Ghazi…[et al.]. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences Vol. 5, no. 2 (Jun. 2021), pp.113-128.
https://search.emarefa.net/detail/BIM-1286967

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Shalar, Muhammad Mutazz Ghazi& Mirza, Jumah& Shriteh, Thana. Synthesis of the new derivative 1- diphenylamine enamine ascorbic Acid, and study of its biological activity. Journal of Natural Sciences, Life and Applied Sciences. 2021. Vol. 5, no. 2, pp.113-128.
https://search.emarefa.net/detail/BIM-1286967

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

رقم السجل

BIM-1286967