تأثيرأوراق و بذورالباباظ على الخلل الحادث في كبد الفئران المستحث برابع كلوريدالكربون

الملخص EN

This study was conducted to investigate the Effect of Papaya(Leaves and seeds) on Liver Disorders in Carbon Tetrachloride-Induced Hepatic Rat.

Rats weighing (140±10) g were used in this study.

The animals were divided into two main groups.

The first main group (n=6) was kept as a control (-ve) group, while rats in the second main group (n=42) were injected by carbon tetrachloride (CCL₄) to induce liver disorder.

Rats a themwas kept as a control (+) group and the other six groups treated with differentpapaya leaves and seedsand mixture of them (2.5% and 5% ) from the basil diet.

At the end of experimental period (28 days), rats were fasted over night before slaughtering and blood was collected then centrifuged to separate the serum and estimate liver functions (AST, ALT and ALP) kidney functions (urea, creatinine and uric acid) serum lipid profile (TC, TG and HDL-c) while LDL-c and VLDL-c were calculated and blood analysis (HB, RBCs, HCT, WBCs and PLT).

The obtained results revealed thattreated groups by CCL₄ led to significant (P≤ 0.05)decrease in body weight gain (% )HDL, total protein, albumin and globulin and increased AST, ALT and ALP, cholesterol, triglycerides, LDL-c, VLDL-c, uric acid, urea, creatinine.

Treating groups which fed onPapaya (Leaves and seeds) and their mixture showed significantly (P≤ 0.05) decreased levels of AST, ALT and ALP, LDL, VLDL, cholesterol, triglycerides, urea, creatinine and uric acid and increase HDL, total protein, albumin and globulin.

It could be concluded that papaya leaves and seedswere effective in protecting against hepatic rats not only decreased the level of AST, ALT and ALP but also has beneficial effect on lipidsserum profile and renal function.