Fecal microbiota transplants : a review of emerging clinical data on applications, efficacy, and risks (2015–2020)
المؤلفون المشاركون
al-Ali, Dana
Ahmad, Aminah
Shafiq, Aminah
McVeigh, Clare
Shiari, Ali
Zakariyya, Daliyah
Bendriss, Ghizlane
المصدر
العدد
المجلد 2021، العدد 1 (30 إبريل/نيسان 2021)، ص ص. 1-20، 20ص.
الناشر
تاريخ النشر
2021-04-30
دولة النشر
قطر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
As the importance of the gut microbiota in health and disease is a subject of growing interest, fecal microbiota transplantation (FMT) was suggested as an attractive therapeutic strategy to restore homeostasis of the gut microbiota, thereby treating diseases that were associated with alteration of the gut microbiota.
FMT involves the administration of fresh, frozen, or dried fecal microorganisms from the gut of a healthy donor into the intestinal tract of a patient.
This rediscovery of the potential benefits of an ancient practice was accompanied by a rapid progression of our understanding of the roles and mechanisms of gut microbes in the pathogenesis of disease.
With a growing number of diseases being associated with dysbiosis or the alteration of gut microbiota, FMT was suggested as an attractive therapeutic strategy to “reset the gut” and initiate clinical resolutions or remissions.
The number of FMT clinical trials is increasing worldwide, but no trials are registered in the Gulf region; this suggested the need for raising awareness of the latest studies on FMT.
This review presented the emergent preclinical and clinical data to give an overview of the potential clinical applications, the benefits, and inconveniences that were worth considering for eventual future testing of fecal transplants in Qatar and the Middle East.
This study highlighted the diversity of methods tested and commented on the variables that can affect the assessment of the effectiveness of FMT in specific diseases.
The risks associated with FMT and the threat of antimicrobial resistance for this therapeutic approach were reviewed.
From gastrointestinal diseases to neurodevelopmental disorders, understanding the roles of the gut microbiota in health and disease should be at the heart of developing novel, standardized, yet personalized, methods for this ancient therapeutic approach.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Ali, Dana& Ahmad, Aminah& Shafiq, Aminah& McVeigh, Clare& Shiari, Ali& Zakariyya, Daliyah…[et al.]. 2021. Fecal microbiota transplants : a review of emerging clinical data on applications, efficacy, and risks (2015–2020). Qatar Medical Journal،Vol. 2021, no. 1, pp.1-20.
https://search.emarefa.net/detail/BIM-1432099
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Ali, Dana…[et al.]. Fecal microbiota transplants : a review of emerging clinical data on applications, efficacy, and risks (2015–2020). Qatar Medical Journal No. 1 (2021), pp.1-20.
https://search.emarefa.net/detail/BIM-1432099
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Ali, Dana& Ahmad, Aminah& Shafiq, Aminah& McVeigh, Clare& Shiari, Ali& Zakariyya, Daliyah…[et al.]. Fecal microbiota transplants : a review of emerging clinical data on applications, efficacy, and risks (2015–2020). Qatar Medical Journal. 2021. Vol. 2021, no. 1, pp.1-20.
https://search.emarefa.net/detail/BIM-1432099
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 16-20
رقم السجل
BIM-1432099
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر