Effects of alpha-lipoic acid on tgf-β1 and urotensin-ii levels in glucocorticoid-induced osteonecrosis in rats
المؤلفون المشاركون
Gokce, Hasan
Dokuyucu, Recep
Koca, Irfan
Tas, Zayn Abidin
Ozcan, Oguzhan
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 22، العدد 4 (30 إبريل/نيسان 2020)، ص ص. 1-9، 9ص.
الناشر
تاريخ النشر
2020-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Background: Osteonecrosis (ON) is a serious health problem, which dramatically reduces the quality of life.
Objectives: In the present study on the rat model of glucocorticoids (GCs) -induced ON, we explored the influence of alpha-lipoic acid on serum levels of TGF-β1 and urotensin-II (U-II) and on histological alteration with respect to fatty degeneration and osteocyte necrosis.
Methods: A total of 32 male Wistar albino rats were equally assigned to four groups, including control, methylprednisolone acetate (MPA), alpha-lipoic acid (ALA), and MPA with ALA (MP1 + ALA).
The animals in MPA group subcutaneously received 15 mg/kg/week during 2 weeks, whereas 100 mg/kg/day ALA was intraperitoneally administered to ALA group during 4 weeks.
The MPA + ALA group had both treatments with the same doses.
ON was confirmed and graded histologically.
Lipid peroxidation and DNA damage levels were immunohistochemically assessed in rats’ bones.
Results: After histopathological examinations, ALA injection attenuated oxidative stress levels through reducing both 8-OHdG-and 4-HNE-positive cells in the femoral head region (P < 0.05).
The U-II and TGF-β1 protein levels significantly decreased after ALA treat- ment in MPA injected animals (P < 0.05, P < 0.01, respectively).
Moreover, there was a strong correlation between U-II and TGF-β1 protein levels (P = 0.019, r = 0.884).
Conclusions: This study is novel with regard to showing the therapeutic effects of ALA on GC-induced ON in rats as well as the strong correlation between the expression levels of U-II and TGF-β1 proteins.
In this regard, ALA may be a therapeutic agent in the treatment of ON patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Koca, Irfan& Dokuyucu, Recep& Tas, Zayn Abidin& Gokce, Hasan& Ozcan, Oguzhan. 2020. Effects of alpha-lipoic acid on tgf-β1 and urotensin-ii levels in glucocorticoid-induced osteonecrosis in rats. Iranian Red Crescent Medical Journal،Vol. 22, no. 4, pp.1-9.
https://search.emarefa.net/detail/BIM-1439419
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Koca, Irfan…[et al.]. Effects of alpha-lipoic acid on tgf-β1 and urotensin-ii levels in glucocorticoid-induced osteonecrosis in rats. Iranian Red Crescent Medical Journal Vol. 22, no. 4 (Apr. 2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1439419
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Koca, Irfan& Dokuyucu, Recep& Tas, Zayn Abidin& Gokce, Hasan& Ozcan, Oguzhan. Effects of alpha-lipoic acid on tgf-β1 and urotensin-ii levels in glucocorticoid-induced osteonecrosis in rats. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 4, pp.1-9.
https://search.emarefa.net/detail/BIM-1439419
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-9
رقم السجل
BIM-1439419
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر