أثر تغيير خواص الوسط على التحلل القاعدي لنموذج نشط من كبريتات الإستر الأحادية

الملخص EN

In this study, an active form of p-nitrophenyl sulfate (4-NPS) was used as a simulation of the biodegradation of mono-ester sulfate, as this substance has suitable properties for following the reaction progress.

Sodium hydroxide was used as medium of reaction and quantities of glycerol used to study the effect of changing the natural properties of the medium on the rate of reaction, glycerol was used to change the density and viscosity of the medium as a mimic of the physiological medium, where glycerol was produced from the alkaline and acidic hydrolysis of triglycerides in the blood.

This research deals with the hydrolysis of 0.05 mM 4-NPS in a medium of 1M NaOH with changing the percentage of glycerol in each reaction with temperature stabilization at 40oC in all reactions, the UV-vis was used to estimate the rate of reaction by following the increase in the concentration of P-Nitro-phenolate.

The obtained results indicated that the rate of reaction speed increased with increasing the percentage of glycerol in the medium of the reaction.

Also, the catalytic hydrolysis by hydroxide ion (1M KOH) was studied at different temperatures to find the thermodynamic parameters (entropy and enthalpy) of this reaction.