صياغة هلامة موضعية محملة بجسيمات مكرومترية اسفنجية حاوية على الكليندمايسين لمعالجة العد الشائع و تقييمها في الزجاج

الملخص EN

The aim of the present investigation was to formulate clindamycin (Cln) as microsponge (MS) based gel to release the drug in controlled manner, reduce the side effects in the treatment of acne.

Microsponge containing clindamycin HCl with four different formulations by changing the proportions of drug, polymer, emulsifier were prepared using emulsion solvent diffusion method.

These formulations were studied for physical characterization and for drug polymer interactions.

Scanning electron microscopy (SEM) images showed the microsponges porous and spherical in shape.

The physical characterization showed that microsponge formulations coded by C1,C3 showed a better loading efficiency, production yield and their particle size were less than 30 μm.

Fourier transform infrared spectroscopy (FTIR) confirmed no significant interactions between excipients and Cln.

C1,C3 microsponge formulation was prepared as gel in carbopol and in-vitro evaluated.

The microsponge formulation gel, C10 was found to be optimized.

C10 released (88.08 %) of drug over 12 hours, and showed viscosity (21454 ± 42) CP, pH of (6.3 ± 0.09) and drug content of (99.38 + 0.14)%.