تطوير طريقة جديدة لتقنيع طعم الأدوية غير المستساغة باستخدام تقنية التمحفظ الصغري

الملخص EN

Taste masking of paracetamol was achieved by preparing amorphous solid dispersion using modified coacervation method.

the method is based on dissolving the drug and polymeric carrier in water adjusted to certain ph level.

then, precipitation of amorphous solid dispersion is performed by gradually changing ph level.

moreover, using solubility enhancing additives such as sodium lauryl sulphate (SLS) and polyethylene glycol (PEG 400) found to be essential in aiding drug aqueous solvation which enhanced drug loading.

solid dispersion between paracetamol and eudragit e was formed and that proved by FT-IR, DSC, and PXRD.

also, paracetamol was released after 2 minutes in 0.1 N hydrochloric acid medium, and the taste of masking forms are accepted from all volunteers.

modified coacervation method does not involve organic solvents, high temperatures, or sophisticated instruments commonly used in taste masking methods.