قياس تركيز مشتقات البارابين في عينات في سرطان البنكرياس

الملخص EN

Parabens are one of the most famous preservatives used from a long time.

Recent studies showed that this substance mimic estrogen, which may have a stimulating effect on cell proliferation abnormally and the induction of cancer, especially breast cancer.

As known estrogen receptors are not confined to the breast, they are distributed in many parts of the body, including the pancreas.

In this study, samples of pancreatic cancer, which is one of the most serious cancers in humans, was investigated.

parabens found in all pancreatic cancer samples at an average concentration (318.8 ± 6.4) ng/g.

Ethyl paraben concentration was the highest followed by methyl paraben then propyl paraben, all patients were diabetic patients.

We suggest further studies to determine if paraben has a role in insulin resistance and in stimulating abnormal proliferation of pancreatic cells by binding to pancreas’s estrogen receptors