صياغة و تقييم في الزجاج لأنظمة الاستحلاب الذاتي لتحسين انحلالية النيفروكزازيد

الملخص EN

The aim of this research was to prepare and evaluate self-emulsifying drug delivery systems (SEDDS) of Nifuroxazide which is indicated as an antimicrobial agent for the treatment of enteric infections.

Surprisingly, a new indication for it has been discovered.

It reduces the viability of multiple myeloma and breast cancer cells.

However, its poor solubility in water limits its use for systemic administration.

So, improving the solubility of NF may enhance its bioavailability and enable its use as a cancer therapy.

The SEDDS of Nifuroxazide were formulated after testing several oils, surfactants and cosolvents.

Their droplets’ size and optical transmittance were determined for evaluation.

In addition, In vitro drug release from these systems was compared to pure drug.

The mixture oleic acid: Tween 20: DMSO in the ratio of 10%: 60%: 30% produced microemulsion with mean droplets ’ size of 13.197 μm and boosted the dissolution rate of NF compared to pure NF at (5, 10, 15, 30, 45) min (P ˂ 0.001) and at 60 min (P ˂ 0.01) according to (One-way ANOVA).

The Drug release percentage of NF SEDDS at 10 min was 96.941 %.

However, the percentage of drug release from intact NF did not exceed 47.946 % at 10 min and 76.118 % at 60 min.

This Formula can be used to prepare self-emulsifying drug delivery system of Nifuroxazide, since it can produce a transparent micro emulsion after dilution with water and enhance Nifuroxazide dissolution rate.