تواتر وجود فيروس الإبشتاين بار EBV في نسج ورمية لمرضى لمفومة هودجكين سوريين

الملخص EN

Epstein-Barr Virus (EBV) is associated with many malignancies, and in particular with Hodgkin's lymphoma.

The EBV virus plays an important role in the development and prognosis of Hodgkin's lymphoma.

There are in Syria a large number of Hodgkin's lymphoma patients who are resistant to chemotherapy and have a bad prognosis.

Our present study aimed to investigate the association of EBV with Syrian Hodgkin lymphoma, and study the prognostic value of EBV.

The study included 60 patients with Hodgkin lymphoma, ranging in age from 4 to 60 years.

Formalin-fixed paraffin embedded blocks of Hodgkin's lymphoma tissue samples were used to detect the presence of LMP1 by immunohistochemistry.

The results showed that (25/60, 41.7%) were positive for LMP1, which demonstrate that 41.7% of tested samples were positive for EBV.

The results also showed that the prognosis for EBV-positive Hodgkin's lymphoma is worse compared to EBV-negative Hodgkin's lymphoma.

We recommend that: the presence of EBV should be investigated for all patients diagnosed with Hodgkin lymphoma .