استقصاء تأثير بعض الفلورو كينولونات على التبدلات النسيجية للشرايين و البنكرياس عند جرذان من النمط STZ-Induced Diabetic Wistar Rats

الملخص EN

Despite the side effects of Fluoroquinolones on the electrocardiogram, and on blood glucose levels, previous research's has shown their importance on some arterial functions clinically, as well as in vitro, by enhancing the action of small conductance calcium-activated potassium channels (SKCa).

All of these effects are considered worthy of attention, especially in diabetics.

This study aims to investigate the effect of treatment with two Fluoroquinolones (Moxifloxacin and Levofloxacin) on histological changes in arteries, and pancreas of wistar rats.

After the development of a type II-like diabetes using STZ, and waiting for aging (4 months), rats were divided into four groups, group 1 : were treated with Moxifloxacin (n=10), group 2 : were treated with levofloxacin (n=10), group 3 : considered as diabetic controls (n=10), and group 4 : considered as non-diabetic controls (n=4).

Plasma insulin levels, body weights, and blood glucose levels were compared at different times for 14 days during the treatment with Fluoroquinolones.

The ability of Fluoroquinolones to lower blood glucose levels was observed.

This effect was greater with levofloxacin than Moxifloxacin, and was associated with higher insulin levels in levofloxacin group than in Moxifloxacin group, and in these two groups, more than diabetic controls, and non-diabetic group.

Histological sections showed necrosis of langerhans islets, and destruction of endothelial cells in the three diabetic groups, but pancreatic necrosis was lower in Levofloxacin group, and endothelial damage was lower in Moxifloxacin group.

In conclusion, the effects of Moxifloxacin and Levofloxacin on the histological changes may vary, as levofloxacin may delay the destruction of langerhans islets, whereas Moxifloxacin may impede diabetic vascular complications.

However, caution must be exercised when using these compounds in diabetic patients by carefully monitoring of blood glucose levels.