انتشار طفرة جين RAS حسب التوزع الجغرافي في الجمهورية العربية السورية

الملخص EN

Background & Aim : Determining the geographical distribution in the Syrian Arab Republic of the spread of RAS gene mutations in colon and rectal cancer patients admitted to Al-Baironi University Hospital.

Materials and Methods : A review study included 488 patients diagnosed with colon cancer and a transitional rectum cancer who reviewed the Al-Baironi University Hospital from 1 January 2018 to 1 January 2021, and their RAS mutation was studied, data and results for the study of the mutation and the identification of the geographical distribution of patients in the Syrian Arab Republic.

Results : The number of patients from the Eastern Region was 54 and ras mutation was present in 24 patients, including 44.44%, 63 patients from the central region, 21 of whom had the mutation 33.33%, and 86 patients from the coastal area Twenty of them have a mutation of 23.25%, 138 patients from the southern region, 33 of whom have the mutation at 23.91%, and 187 patients from the northern region, 78 of whom have the mutation at 53.06%.

Conclusion : Ras mutations should be analyzed in all patients with colon cancer and a transitional rectum cancer, and it is important to know the geographical distribution of the spread of the mutation so that patients are well followed up.