Association of the UCP2 –866GA polymorphism with type 2 diabetes and obesity in Saudi population
المؤلف
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 10، العدد 2 (30 نوفمبر/تشرين الثاني 2009)، ص ص. 228-236، 9ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2009-11-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Diabetes mellitus is emerging as a major public health problem allover the world particularly Saudi Arabia.
Recent studies reported that Uncoupling Protein 2 (UCP2) was associated with obesity and type 2 diabetes (T2D).
Aim of the Study: This study was conducted to clarify the contribution of polymorphism in UCP2 in obesity and T2D in the Saudi population.
Subjects and Methods: The distribution of the –866G/A polymorphism was examined in a case-control study including samples from 110 obese patients, 81 T2D patients, 96 obese-T2D patients and 100 healthy unrelated Saudi subjects.
The –866G/A polymorphism were determined by using PCR/RFLP (polymerase chain reaction/restriction fragment length polymorphism) techniques.
Results: The results of this study showed that the frequency of the GG genotype was significantly higher in both obese and T2D patients (p-value= 0.0001, p-value= 0.014, respectively) compared with healthy control.
The G allele was significantly associated with increase risk of obesity (odd ratio, OR: 3.3; 95% confidence interval, CI: 1.37-7.98), but not with T2D (OR, 1.97; Cl, 0.80-4.87).
In obese-T2D patients group, no significant correlation with –866G/A polymorphism (p= 0.067; OR, 1.21; Cl, 0.25-2.80).
This unreeled study suggested that the G allele of UCP2 –866G/A polymorphism was related to obesity, which indicated the possible role of this polymorphism in causing metabolic syndrome.
Conclusion: This study concluded that the G allele of UCP2 –866G/A polymorphism might be related to obesity and T2D which might be used as a predictive marker for obesity and T2D.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tayyib, Muhammad Tahir. 2009. Association of the UCP2 –866GA polymorphism with type 2 diabetes and obesity in Saudi population. The Egyptian Journal of Medical Human Genetics،Vol. 10, no. 2, pp.228-236.
https://search.emarefa.net/detail/BIM-203790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tayyib, Muhammad Tahir. Association of the UCP2 –866GA polymorphism with type 2 diabetes and obesity in Saudi population. The Egyptian Journal of Medical Human Genetics Vol. 10, no. 2 (Nov. 2009), pp.228-236.
https://search.emarefa.net/detail/BIM-203790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tayyib, Muhammad Tahir. Association of the UCP2 –866GA polymorphism with type 2 diabetes and obesity in Saudi population. The Egyptian Journal of Medical Human Genetics. 2009. Vol. 10, no. 2, pp.228-236.
https://search.emarefa.net/detail/BIM-203790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 233-236
رقم السجل
BIM-203790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر