Prognostic value of tnf α mrna and vegf mrna expression in patients with chronic hepatitis c genotype-4, with and without cirrhosis and hepatocellular carcinoma to predict disease outcome
المؤلفون المشاركون
Kishta, S. A.
Abd al-Hadi, A. Aql M.
Hammam, O.
Abeya, S.
Abd al-Rauf, E.
المصدر
Journal of the Egyptian Society of Parasitology
العدد
المجلد 40، العدد 2 (31 أغسطس/آب 2010)، ص ص. 515-529، 15ص.
الناشر
الجمعية المصرية لعلم الطفيليات
تاريخ النشر
2010-08-31
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الموضوعات
الملخص EN
The study aimed to clarify whether vascular endothelial growth factor mRNA (VEGF mRNA) and TNFα mRNA in the HCC tissues on top of HCV with and without cirrhosis obtained from specimens after curative hepatic resection has a prognostic value and recurrence predictive value compared to other tumor criteria.
A total of 160 patients were studied.
The preoperative laboratory, radiological and staging to patients was done.
Using in situ hybridization technique, VEGF mRNA and TNFα mRNA were determined in liver tissues of, 10 controls, 50 with HCC, 50 with HCV without cirrhosis and 50 HCV with cirrhosis. The results showed that in HCC cases there was positive correlation between increasing age, loss of weight, INR and AFP but not in other cases of CHC with or without cirrhosis.
AFP, vascular invasion, encapsulation, tumor size and grade and platelet count were related to patients outcome and recurrence of tumor after follow up of most cases for 3 years.
The expression of VEGF in liver tissues was proportional to progress of viral hepatitis to cirrhosis with more expression in cases progressed to malignant changes.
More expression of VEGF in HCC was more evident with intense expression in cases with Vascu-lar and capsular invasion and higher level of AFP.
Expression of TNF α mRNA and VEGF mRNA shows increasing expression with positive correlation to progression of viral hepatitis to cirrhosis with more positive with cases devel-oped HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kishta, S. A.& Abd al-Hadi, A. Aql M.& Hammam, O.& Abd al-Rauf, E.& Abeya, S.. 2010. Prognostic value of tnf α mrna and vegf mrna expression in patients with chronic hepatitis c genotype-4, with and without cirrhosis and hepatocellular carcinoma to predict disease outcome. Journal of the Egyptian Society of Parasitology،Vol. 40, no. 2, pp.515-529.
https://search.emarefa.net/detail/BIM-251915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kishta, S. A.…[et al.]. Prognostic value of tnf α mrna and vegf mrna expression in patients with chronic hepatitis c genotype-4, with and without cirrhosis and hepatocellular carcinoma to predict disease outcome. Journal of the Egyptian Society of Parasitology Vol. 40, no. 2 (Aug. 2010), pp.515-529.
https://search.emarefa.net/detail/BIM-251915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kishta, S. A.& Abd al-Hadi, A. Aql M.& Hammam, O.& Abd al-Rauf, E.& Abeya, S.. Prognostic value of tnf α mrna and vegf mrna expression in patients with chronic hepatitis c genotype-4, with and without cirrhosis and hepatocellular carcinoma to predict disease outcome. Journal of the Egyptian Society of Parasitology. 2010. Vol. 40, no. 2, pp.515-529.
https://search.emarefa.net/detail/BIM-251915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 527-529
رقم السجل
BIM-251915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر