Antibacterial activity of functionalized 1-(2',4'-dihydroxy-5'- substituted phenyl)‎-3-thienyl-propane-1,3-diones bearing potential o,o,s-pharmacophores

الملخص EN

A series of highly functionalized 1-(2', 4’-dihydroxy-5'-substituted phenyl)-3-thienyl-propane- 1, 3-diones 3a-g have been produced upon Baker-Venkataraman rearrangement of 4- hydroxy-5-substituted-2-thienoyloxyacetophenones 2a-g using dimethylsulphoxide in NaOH.

All the synthesized motifs 3a-g were confirmed by the spectroscopic analyses and evaluated for antibacterial efficacy against different pathogens.