دراسة تأثير عقار أدرياميسين على الحويصلات الناضجة و البويضات عند الفئران البيضاء، و مقارنة ذلك مع النشاط التناسلي عند النساء المتعاطيات لهذا العقار

الملخص EN

Adriamycin is one of the most anti-cancer drugs used in treating many cancer tumors, and its importance comes from the cytotoxic effect on the cancer cells, but this effect goes beyond cells to affect the healthy cells in areas of rapid reproduction such as Granulose cells and Oocytes in Graffian follicles.

To know the negative effect of this drug on the reproductive activity in women taking this drug in terms of disturbances in the menstrual cycle, menopause at an early stage and the absence of pregnancy; we studied histological changes of the mature follicles (Graffian follicles) and changes in the cellular structure of oocytes in Albino Mice injected with a single dose of Adriamycin in the peritoneal cavity, then we linked the results of this study with a field hormonal statistical study on women taking this drug.

The result of this study pointed out that the cause of the disturbances in the sexual activity among those women may be due a change in the structure of the cells and disappearance of yellow bodies (Corpus luteum) and which results in absence of ovarian sexual hormones (progesterone and estrogen) responsible for regulating the menstrual cycle and preparing the uterus for pregnancy.