Combined a-thalassemia and hemoglobin j-Iran (p77 his -► asp)‎. a family study in southern Iran

المؤلفون المشاركون

Karimi, M.
Afrasiabi, A. R.
Dehghani, S. J.
Dashtrazhen, A. Amiri
Nasirabadi, Sh.
Dehbozorgian, J.
Murshedi, N.
Imanifard, Sh.
Mehrpoor, Sh.
Gerdabi, Sh.

المصدر

Iranian Red Crescent Medical Journal

العدد

المجلد 13، العدد 8 (31 أغسطس/آب 2011)، ص ص. 586-589، 4ص.

الناشر

المستشفى الإيراني

تاريخ النشر

2011-08-31

دولة النشر

الإمارات العربية المتحدة

عدد الصفحات

4

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

We report a 23-year-old man and three members of his family with Hb J-Iran confirmed by electrophoresis, chain separation by high performance liquid chromatography and sequencing.

Alpha thalassemia was also confirmed in two family members.

The substitution at β77 led to a higher negative charge of the βJ-Iran subunit, which enhanced its electrostatic attraction for the normal positively-charged α subunit.

Therefore, more Hb J-Iran than Hb A forms in the red blood cells of heterozygotes.

In α-thalassemia, the more attractive βJ-Iran subunit out-competes βA subunits in forming assemblies with deficient α subunits, so even more Hb J-Iran was formed.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Dehghani, S. J.& Dashtrazhen, A. Amiri& Nasirabadi, Sh.& Dehbozorgian, J.& Afrasiabi, A. R.& Murshedi, N.…[et al.]. 2011. Combined a-thalassemia and hemoglobin j-Iran (p77 his -► asp). a family study in southern Iran. Iranian Red Crescent Medical Journal،Vol. 13, no. 8, pp.586-589.
https://search.emarefa.net/detail/BIM-268097

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Dehghani, S. J.…[et al.]. Combined a-thalassemia and hemoglobin j-Iran (p77 his -► asp). a family study in southern Iran. Iranian Red Crescent Medical Journal Vol. 13, no. 8 (Aug. 2011), pp.586-589.
https://search.emarefa.net/detail/BIM-268097

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Dehghani, S. J.& Dashtrazhen, A. Amiri& Nasirabadi, Sh.& Dehbozorgian, J.& Afrasiabi, A. R.& Murshedi, N.…[et al.]. Combined a-thalassemia and hemoglobin j-Iran (p77 his -► asp). a family study in southern Iran. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 8, pp.586-589.
https://search.emarefa.net/detail/BIM-268097

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 589

رقم السجل

BIM-268097