The association between sporadic Alzheimer’s disease and the human ABCA1 and APOE gene polymorphisms in Iranian population
المؤلفون المشاركون
Khorshid, H. R. Khorram
Gozalpour, E.
Kamali, K.
Ohadi, M.
Karimlu, M.
Shahhusayni, M. H.
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 13، العدد 4 (30 إبريل/نيسان 2011)، ص ص. 256-262، 7ص.
الناشر
تاريخ النشر
2011-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Apo lipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain.
ATP-binding cassette transporter A1 (ABCA1) gene on chromosome 9, which has been known by genome-wide AD linkage study, has an important role in cellular cholesterol efflux.
This study determines the association between sporadic AD and the human ABCA1 and APOE gene polymorphisms in Iranian population.
Methods : 154 AD cases and 162 control subjects from Iranian population were genotyped for APOE genotypes and ABCA1 polymorphism (R219K).
Results : the frequency of ε2ε3 genotype was higher in control subjects comparing AD patients but was not significant (13% versus 5.8%) and ε3ε4 genotype frequency was significantly higher in AD cases comparing with control subjects.
APOE-ε2 allele frequency in cases was lower than control subjects but this difference was not significant (4.5% versus 8%).
Individuals carrying ε4 allele, developed AD 6.5 times more than non-carriers (OR = 6.52, 95%CI = 2.63-16.17).
There was no significant association between ABCA1 polymorphism and AD.
Conclusion : unlike other studies, R219K polymorphism was not dependent on gender and APOE-ε4 allele and there was no association between APOE and ABCA1 in AD patients compared to controls.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khorshid, H. R. Khorram& Gozalpour, E.& Kamali, K.& Ohadi, M.& Karimlu, M.& Shahhusayni, M. H.. 2011. The association between sporadic Alzheimer’s disease and the human ABCA1 and APOE gene polymorphisms in Iranian population. Iranian Red Crescent Medical Journal،Vol. 13, no. 4, pp.256-262.
https://search.emarefa.net/detail/BIM-268285
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khorshid, H. R. Khorram…[et al.]. The association between sporadic Alzheimer’s disease and the human ABCA1 and APOE gene polymorphisms in Iranian population. Iranian Red Crescent Medical Journal Vol. 13, no. 4 (Apr. 2011), pp.256-262.
https://search.emarefa.net/detail/BIM-268285
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khorshid, H. R. Khorram& Gozalpour, E.& Kamali, K.& Ohadi, M.& Karimlu, M.& Shahhusayni, M. H.. The association between sporadic Alzheimer’s disease and the human ABCA1 and APOE gene polymorphisms in Iranian population. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 4, pp.256-262.
https://search.emarefa.net/detail/BIM-268285
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 261-262
رقم السجل
BIM-268285
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر