Pharmacological and toxicological studies on 3-amino-5-acetoxy-2-bromo-l, 4-naphthoquinone derivatives as analgesic, antipyretic and anti-inflammatory agents

الملخص EN

The present study included a comparative investigation of two synthetic compounds: 5-acetoxy-2-bromo-3-(4’-carboxyphenyl-arnino) -1, 4-naphthoquinone, and 5-acetoxy-2-bromo-3-(3'-hydroxy-4'-carboxy phenylamino)-l, 4-naphthoquinone with aspirin and indomethacin as standards.

However, administered oral doses of the synthetic compounds caused inhibition of rat's paw oedema induced by carageenin and reduced body temperature of yeast-induced hyper¬thermic rats.

They induced anti-nociception in rats with inflamed paw.

On isolated guinea pig ileum, the synthetic compounds caused inhibition of arachidonic acid contractile response.

Addition of the compounds to platelet-rich plasma exhibited anti-aggregatory activity on ADP-induced platelet aggregation.

On strip of rat's stomach, the two compounds caused inhibition of arachidonic acid contractile response in presence of lung homogenate.

The two compounds possess antipyretic, analgesic and anti-inflammatory activities, which could be attributed to the inhibition of prostaglandin synthesis.

Toxicity studies showed some changes in biochemical constituents especially alkaline phosphate but did not exhibit changes in hematological parameters.