The effect of bioglue® on cerebral cortex in experimental rats

الملخص EN

Background : BioGlue ® is a newly introduced sealant applied by several cardiovascular surgeons to seal graft anatomizes.

This study was carried out to determine the effect of a synthetic Bio Glue ® on the repair of meninges in comparison with contemporary bioadhesives.

Methods : A synthetic BioGlue ® was provided by combining 45 % human serum albumin and 10 % glutaraldehyde.

Forty Wistar female rats were randomly divided into 4 equal groups (Two case and two control groups).

After craniotomy, dural incision was performed and the motor cortex was exposed.

In the case group, the motor cortex was exposed to Bio Glue ® and in the control group, the incision was closed without application of ®.

Bio Glue The rats were studied his pathologically after 5 and 14 days post craniotomy.

Results : Synthetic BioGlue ® caused an acute inflammatory response that resulted in a delayed gliosis in the superficial cerebral cortex, but the deep layers and adjacent areas of cortex were spared.

Inflammatory changes and gliosis did not cause cell apoptosis or necrosis.

Histopathological changes did not have any clinical significance as they were not accompanied by any neurological deficit or motor weaknesses and exposure to synthetic Bio Glue ® could not cause any clinically significant neurological deficit either.

Conclusion : the simplicity of producing this new synthetic BioGlue ® and its relative low cost, compared to other similar glues, opens a new horizon to the use of this synthetic Bio Glue ® in the neurosurgical field.