Evaluation of α1-antitrypsine and reduced glutathione in Iraqi patients of diabetes mellitus type ii

الملخص EN

In order to investigate the levels of reduced glutathione GSH and α1-antitrypsine in the sera of 20 type 2 diabetic patients and 10 healthy subjects, were enrolled in this study.

A significant reduction in GSH level was found in the patient group compared with control.

On the other hand a significant elevation in α1-antitrypsine in patient compared with control was observed.

Correlation between α1-antitrypsine and reduced glutathione was found to be positive (+Ve) for diabetes mellitus type2 patients and negative (-Ve) for healthy control with r values 0.257 and – 0.339 respectively.

In conclusion the depletion of GSH as antioxidant defense insured higher free radical generation in diabetic patients which is confirmed by the high α1-antitrypsine level in the sera.