عزل و تشخيص مركبات حامض الكافائيك و يوجينول و فينول-2-ميثوكسي-3-(2-بروبينيل)‎ من ثمار نبات الخرنوب و دراسة فعاليتها كأدوية مضادة للبكتيريا المرضية للمجاري البولية

الملخص EN

propenyl) were isolated and identified from Prosopis farcta fruits .

The is recommended to use the phenolic compounds as herbal therapeutic substituents for treatment of urinary tracts infections instead of antibiotics physical and chemical methods were used in identification such as UV-vissible and infrared spectra , thin layer chromatography , column chromatography , fanctional groups test, gas-chromatography-mass spectrum and melting point .

The medicinal The phenolic compounds (caffeic acid,eugenol and phenol -2- methoxy -3-(2-activity for compounds isolated with concentration ( 150 mg / ml ) , were studied against five types of pathogenic bacteria of urinary tracts infections, are Escherichia coli , Staphylococcus aureus , Proteus sp.

, Klebsiella sp.

and Pseudomonas aeraginosa .

The minimal inhibitory concentration and cellular toxicity of these compounds , were determined , also the medicinal activity of isolated phenolic compounds , was compared with some antibiotics such as ampicillin , cephlaxin , ciprofloxacin , streptomycin and tetracycline .

The phenolic compounds showed that they have a highest medicinal effect for inhibition of bacteria growth than antibiotics .

It was found that isolated compounds have no a toxic effect against red blood cells of human .

As a result , it is recommended to use the phenolic compounds as herbal therapeutic substituents for treatment of urinary tracts infections instead of antibiotics having side effects but this work demands further clinical and pharmaceutical studies .

Keywords : Prosopis farcta , caffeic acid , phenol-2- methoxy-3- (2- propenyl) , eugenol, medicinal activity , pathogenic bacteria , urinary tracts infections