التغيرات المرضية النسيجية في القلب و الكلية المعرضة للبروتين السام (M)‎ لبكتريا Streptococcus pyogenes

الملخص EN

M-Protein was extracted from cell wall of Streptococcus pyogenes, isolated from patients.

Lab animals (white mice) were divided into two groups (2 mice) the first one represents the control, whereas the animals of second group (8 mice) were injected intramuscularly with M protein phenomenon variation occurred in the body of the injected mice, showed arthritis, heart revealed enlargement, kidney showed hypertension.

The histopathological changes in heart and kidney tissue showed a thickness in the blood vessels of the heart tissue, it results from the cross reaction and deposition of the immune complexes which formed between the antibodies of M protein antigen of blood vessels.

The kidney tissue of injected mice with M protein revealed changes in the lining epithelium of bowman capsule and hypertention in glomeruli.

These results confirmed the toxic effect of M protein on heartand kidney tissues.