تأثير المستخلص الكحول الاثيلي و خلات الاثيل لنبات ورد الختمة Hibiscus rosa sinunsis في خصوبة إناث الفئران البيض

الملخص EN

The aim of this study to search the biological activity of ethyl alcohol and ethyl acetate extract of hibiscus rosa sinensis and its effect on the fertility by using 72swiss female albino mice.

These female were divided into three groups and treated with two doses (125-250) mg / Kg for three period) 4 ; 8 ; 12 days.

This result revealed the following - A significant increase (p<0.05) in the total body weight in term of female mice that treated by ethyl acetate only comparing with control group, while there was no significant change occurred in the total body weight in term of female mice that treated by ethyl alcohol. - A significant decrease (p < 0.05) in the weight of ovaries and (p < 0.05) in the weight of uteruses of female mice that treated by both two doses of ethyl acetate and ethyl alcohol extract comparing with control group, at then ethyl acetate produced higher activity in decrease weight of ovaries and increase weight of uterus as comparing with ethyl alcohol extract - The histological study showed a significant (p < 0.05) decrease in diameters of ovaries and number of primary & secondary ovarian follicles and (number, diameters) of graffian follicles of female mice that treated with two concentration of ethyl acetate and alcohol extract comparing with control group - The results of female fertility don't show sperms in vaginal smear unless beyond a period of time and pregnancy period would belate through daily fooling for (30) days, a clear decrease in numbers of embryons of female mice that treated by two doses for one period of injection of (12) days of ethyl acetate and alcohol extract comparing with control group.