Thrombin generation ِamong Sudanese essential hypertensive patients

الملخص EN

This is a descriptive, prospective analytical case-control based study conducted in Khartoum State Teaching Hospitals during the period of October 2003 to January 2008 to determine the thrombin generation among Sudanese hypertensive patients.

Two hundred patients (200) and fifty normal controls (50) were studied.

The results showed a significant correlation between hypertension and family history of patients and non significant correlation between family history of hypertension and the gender of the study group.

Most hypertensive patients in the study group were presented with a duration range from 1 month up to 5 years using antihypertensive drugs as a treatment.

The results showed a non significant difference between the mean level of patients and controls in prothrombin fragment 1+2 (F1+2) (p=0.925) and thrombin antithrombin complex (TAT) (p=0.867).

Prothrombin fragment 1+2 level (p= 0.012) was significantly correlated to severity of hypertension (stage II), while thrombin antithrombin complex level did not show significant (p=0.124) correlation to the severity of the disease.

Both circulating markers of thrombin generation (Prothrombin fragment 1+2 and thrombin antithrombin complex) were significantly (p=0.000) correlated to the duration of hypertension.

The results obtained indicated that measurement of prothrombin fragment 1+2 could be of use in identifying a "high-risk" group of hypertensive patients who are likely to develop thrombotic events.

KEYWORDS: Hypertension, Thrombosis, Hemostasis, Thrombin generation