الكرب التأكسدي لدى النساء العقيمات في محافظة نينوى

الملخص EN

The research included a study of oxidative stress in infertility female for two types (Primary and secondary) in Ninava governorate, beside of the effects of Body mass index (BMI) on oxidative stress of infertility through measuring (17) oxidants and antioxidants parameters.

The study was carried out on (223) sample of women (age 19 – 45 year).

The infertility (179) divided into two groups (depending on types of infertility).

Non infertility (44) were included in the study as control with similar age and sex.

The group of primary infertility showed significant decrease concentrations of vitamin C, vitamin E, glutathione, total bilirubin, folic acid and zinc when compared with control, while there was a significant increase of: glutathione S-transferase(GST), albumin, copper, iron, ceruloplasmin (Cp), moloudialehyde (MDA) and peroxynitrite.

While, the secondary infertility showed significant decrease concentrations of vitamin C, vitamin E, GSH, total bilirubin, folic acid, zinc and copper, and there was a significant increased of : GPx, GST, Cp, MDA and peroxynitrite.

Moreover, the oxidative stress showed increased in secondary infertility compared with Primary infertility because of increased of antioxidants and decreased of oxidants in primary infertility.

Beside of, the study showed the effect of BMI on the oxidants and antioxidants levels.

The results revealed that there were direct correlation between BMI increase with the concentrations of (MDA, peroxynitrite) and inverse correlation with the concentrations of antioxidants (For example vitamin C, vitamin E, SOD, total bilirubin, folic acid and uric acid).