Inclusion compounds between α-, β-, y- and HP-β-cycodextrins with betamethasone : a theoretical and experimental study using phase solubility diagram and molecular mechanics
مقدم أطروحة جامعية
مشرف أطروحة جامعية
أعضاء اللجنة
Ghanim, Raid Ahmad
Ali, Basim Faris
al-Umari, Mahmud Mustafa
الجامعة
جامعة آل البيت
الكلية
كلية العلوم
القسم الأكاديمي
قسم الكيمياء
دولة الجامعة
الأردن
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2008
الملخص الإنجليزي
The objectives of this work are to study the interaction of [3-methasone with different types of CDs (a-,p-,y-,and HP-|3-CD).
Different techniques were used in this investigation including phase solubility diagram (PSD), differential scanning calorimetry, scanning election microscope (SFM) and molecular modeling. The PSD results indicated that the tendency of |3-methasone to bind with CDs follows the order y-CD< a-CD < HP-p-CD < p-CD.
This proved that size fit plays on important role in inclusion complexation.
The driving force of the (3-methasone / CDs complexation is the enthalpy, while it is related by entropy changes.
The negative entropy change by indicated that conformational changes is the dominate rather than the relese of water solubility for the CD cavity and those form an ice-burg structure around the drug. Molecular mechanics (MM+) study revevled that the dominate driving force of inclusion complexation of the electrostatic energy.
The binding energies of both approach indication possible isomeric complex formation.
The different scanning calorimetry (DSC) and scanning electron microscope (SEM) proved the formation of inclusion complex in solid state. The study showed that formation of complexes between P-methasone and CD is driven by enthalpic factors.
Formation of complexes is favorable, calculation and simulation computer program approved that (Hyperchem®). Complex AH° (KJ/mol) AS° (J/molK) AG° (KJ/mol) K„ (dm^ol"1) P-meth/p-CD -44.67 -89.23 -18.07 1350.70 The solubility of P-methasone increased by complexation on all temperatures study. By the molecular modeling the more stable structures and the inclusion process for P-methasone /CD's inclusion complexes were studied by molecular mechanics, amber force field because it need a less time . The nonbonding van der Waals interactions are responsible for the stability of P-methasone/CD's complexes.
التخصصات الرئيسية
عدد الصفحات
85
قائمة المحتويات
Table of contents.
Abstract.
Chapter One : introduction.
Chapter Two : theoretical background.
Chapter Three : experimental.
Chapter four : results and discussion.
References.
Chapter five: References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Anzi, Maram M.. (2008). Inclusion compounds between α-, β-, y- and HP-β-cycodextrins with betamethasone : a theoretical and experimental study using phase solubility diagram and molecular mechanics. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-311560
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Anzi, Maram M.. Inclusion compounds between α-, β-, y- and HP-β-cycodextrins with betamethasone : a theoretical and experimental study using phase solubility diagram and molecular mechanics. (Master's theses Theses and Dissertations Master). Al albayt University. (2008).
https://search.emarefa.net/detail/BIM-311560
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Anzi, Maram M.. (2008). Inclusion compounds between α-, β-, y- and HP-β-cycodextrins with betamethasone : a theoretical and experimental study using phase solubility diagram and molecular mechanics. (Master's theses Theses and Dissertations Master). Al albayt University, Jordan
https://search.emarefa.net/detail/BIM-311560
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-311560
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر