تأثير مستخلص نبات القرفة المائي (الدارسين)‎ (Cinnamomum zeylanicum)‎ و (Cinnamomumcassia)‎ على التغيرات الكيموحيوية لمرض السكري المستحدث بالالوكسان

الملخص EN

Phenolic compounds and active compounds were extracted from the cinnamon in an attempt to produce a drug of vegetable origin for the diabetes of treatment.

the results showed the water extract of cinnamon contained (Phenols, flavonoids, tannins, glycosides, coumarins, resins, alkaloids, terpenes, and saponin).

Cinnamon effective groups phenolic, Aldahid, Esturian, hydrocarbon, alcohol and carbocsilic compounds were diagnosed by using Infrared spectroscopy (IR).

Morever the half deadly dose (LD50) was also examined by testing the toxicity of on cinnamon extract.

Rats were used as laboratory animals in conducting the experiments.

The rats were fed by the dose (100, 200, 300, 500 mg/ kg of body weight).

The results have shown that there is no toxic effect in the cinnamon extract.

Similar concentrations were used to determine the effective dose of the extracts in reduces the level of glucose in the blood of healthy animals.

It is noticed, that the dose of (300) mg/kg of the animal body weight has proved to be the most decreased efficient as it decreased.

and after the expiry of the experiment for peroid 30 days of induced diabetes for alloxan and cinnamon extract and Aldaanal treatmed for been animals fasting 18 hours for the measuring the level of glucose in the blood serum of animals has been showin low level of glucose in the serum, a significant decrease following giving cinnamon extract comparison with the control group (the infected) and predominete Aldaanal treated group.

Biochemical tests showed the concentration of each the following went down cholesterol (TC), Triglyseride (TG), low density lipoprotein (LDL- C) in the group wihch were treated with cinnamon extract in comparison with the positive groups (infected) throughout the duration and (30) days and predominate Aldaanal treated group.

while the high density lipoprotein (HDLC) level increased in cinnamon extract group But (HDL-C) concentration level decreased in the control group (infected), extract has be proven for Efficiency of treatment.

Concentrations of enzymes (GOT) and (GPT) were measured to determine the function of liver where by their levels went up during the duration (15) days with all the groups treated.

However, after the (30) days the levels went down in both groups of rats which were treated whith extract of cinnamon compared with two groups, the control (positive) and the Aldaanal.