Acute and chronic interaction study between acetylsalicylic acid (aspirin) and captopril atdifferent doses
العناوين الأخرى
دراسة التفاعل الحاد و المزمن بين الأسبرين و الكابتوبريل بمختلف الجرع في الجرذان
المؤلفون المشاركون
Hadi, Najah Raiesh
Mahd, Sadiyah Salih
Abbas, Durayd Abd al-Hadi
المصدر
العدد
المجلد 12، العدد 1 (30 يونيو/حزيران 2009)، ص ص. 268-276، 9ص.
الناشر
تاريخ النشر
2009-06-30
دولة النشر
العراق
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
The present studies were conducted to determine acute and chronic toxicity of aspirin and captopril given alone or in combination in seventy rats were used, 21 rats for acute toxicity (LD50) of aspirin, captopril and their combination in single dose, while the other forty nine rats were used to determine chronic toxicity effect which were divided into 4 groups, the control group (7 rats) received distilled water, the other three treatment groups each group (14) rats were divided into two subgroups T1 and T2 according to the following oral daily dosing regiment ( aspirin subgroup 2 and 4 Mg / kg , captopril, 6 and 12 mg/kg and aspirin + captopril ( 2 + 6 mg / kg and 4 + 12 mg / kg) respectively. LD50 was measured for all groups after their chronic treatment to determine chronic index. The results of acute toxicity (LD50) were, for captopril 4.3705 g / kg, aspirin 5.3705 G / kg and their combination (captopril 2.1295 g / kg + 2.6295 g / kg aspirin), respectively that reduced after chronic drug exposure to 3.1315 g / kg captopril, 3.1295g / kg aspirin and captopril 1.6315 g / kg + 2.1315 g / kg aspirin. Isobolographic analysis of two drug LD50 showed that there were an additive effect after acute toxic exposure and antagonism after chronic one No accumulation was reported between the two drugs and their combination after 3 month daily treatment according to the results of chronic index of all treated groups. This study indicate that LD50 isobolographic analysis for captopril and aspirin showed an additive effect after acute exposure and antagonism after chronic administration and no accumulation effect for both drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abbas, Durayd Abd al-Hadi& Hadi, Najah Raiesh& Mahd, Sadiyah Salih. 2009. Acute and chronic interaction study between acetylsalicylic acid (aspirin) and captopril atdifferent doses. Kufa Medical Journal،Vol. 12, no. 1, pp.268-276.
https://search.emarefa.net/detail/BIM-326776
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hadi, Najah Raiesh…[et al.]. Acute and chronic interaction study between acetylsalicylic acid (aspirin) and captopril atdifferent doses. Kufa Medical Journal Vol. 12, no. 1 (2009), pp.268-276.
https://search.emarefa.net/detail/BIM-326776
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abbas, Durayd Abd al-Hadi& Hadi, Najah Raiesh& Mahd, Sadiyah Salih. Acute and chronic interaction study between acetylsalicylic acid (aspirin) and captopril atdifferent doses. Kufa Medical Journal. 2009. Vol. 12, no. 1, pp.268-276.
https://search.emarefa.net/detail/BIM-326776
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 275-276
رقم السجل
BIM-326776
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر